Facile synthesis of S-arylisothioureas via the S-arylation of arylthioureas with aryl iodides in water |
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Authors: | Xing Liu Hui Zhu Shi-Bo Zhang Yu Cheng Han-Ying Peng Zhi-Bing Dong |
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Institution: | 1. School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China;2. Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany |
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Abstract: | An environmentally benign, simple and highly efficient protocol for the synthesis of S-arylisothiourea derivatives has been achieved in good to excellent yields by reacting a series of aryl iodides with arylthioureas, using inexpensive CuSO4·5H2O as catalyst in water without PTC (phase transfer catalyst). The protocol features easy performance, good to excellent yields, good tolerance towards a variety of functional groups, which could be useful for the preparation of some biologically active compounds. |
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Keywords: | Arylthiourea Synthesis Copper Water |
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