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Facile synthesis of S-arylisothioureas via the S-arylation of arylthioureas with aryl iodides in water
Authors:Xing Liu  Hui Zhu  Shi-Bo Zhang  Yu Cheng  Han-Ying Peng  Zhi-Bing Dong
Institution:1. School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China;2. Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany
Abstract:An environmentally benign, simple and highly efficient protocol for the synthesis of S-arylisothiourea derivatives has been achieved in good to excellent yields by reacting a series of aryl iodides with arylthioureas, using inexpensive CuSO4·5H2O as catalyst in water without PTC (phase transfer catalyst). The protocol features easy performance, good to excellent yields, good tolerance towards a variety of functional groups, which could be useful for the preparation of some biologically active compounds.
Keywords:Arylthiourea  Synthesis  Copper  Water
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