A green protocol for one pot synthesis of benzosuberone tethered thiadiazolopyrimidine-6-carboxylates using PEG-400 as potent anti-proliferative agents

A new concise and facile method was explored to synthesize a collection of new benzosuberone based thiadiazolo 3,2-a] pyrimidine-6-carboxylates using polyethylene glycol (PEG), which could be regarded as the derivatives of the hybrid scaffolds of bioactive natural benzosuberone and heterocyclic thiadiazolo3,2-a]pyrimidine. The structures of the synthesized compounds were characterized by ¹H, ¹³C NMR, MS and IR; and their anti-proliferative activity was evaluated against four human cancer cell lines; A549, SKNSH, HeLa and MCF-7. Among the tested compounds, compound 8k showed the most prominent activity against all the cell lines and these results may lay the foundation for further design of novel anti-proliferative agents.