Humulene derivatives from Saharian Asteriscus graveolens |
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| Authors: | Leila Hammoud Francisco León Ignacio Brouard Javier Gonzalez-Platas Samir Benayache Paul Mosset Fadila Benayache |
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| Affiliation: | 1. Unité de recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques, Université Frères Mentouri, Constantine 1, Route d’Aïn El Bey, 25000 Constantine, Algeria;2. Instituto de Productos Naturales y Agrobiología-C.S.I.C., Av. Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain;3. Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1345 Center Dr, MSB P6-07, Gainesville 32610, FL, USA;4. Departamento de F?sica, Universidad de La Laguna, Av. Astrofísico Fco. Sánchez s/n, E-38204 La Laguna, Tenerife, Spain;5. Université de Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35700 Rennes, France |
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| Abstract: | Three new sesquiterpene-humulenes, (?)- asteriscunolides I (1), J (2) and (?)-(2Z,6E,9Z)-8-oxo-1α-acetoxy-2,6,9-humulatrien-12-oic acid (3) were isolated from the leaves-flowers of the Saharan medicinal plant Asteriscus graveolens along with six known compounds. The structures of the compounds were determined on the basis of spectroscopic mono and bidimensional NMR, mass spectrometry and by single-crystal X-ray diffraction. Compounds 1–3 were evaluated for cytotoxic assay, no significant activity was detected. |
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| Keywords: | Humulanolides Sahara medicinal plants Asteraceae |
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