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A simple and efficient synthesis of new fluorophore 4-hydroxy pyrazolo[1,5-a]pyridines through a tandem reaction
Authors:Peiling Yan  Guiyun Duan  Ruixue Ji  Yanqing Ge
Institution:1. College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, Shandong 266071, PR China;2. School of Chemistry and Pharmaceutical Engineering, Taishan Medical University, Taian, Shandong 271016, PR China
Abstract:The cascade reaction of ethyl pyrazole-5-carboxylate with α, β-unsaturated ester leading to 4-hydroxy pyrazolo1,5-a]pyridine derivatives has been developed. A possible mechanism is proposed. The resulting pyrazolo1,5-a]pyridines present strong fluorescence in solutions.
Keywords:Cascade  Pyrazolo[1  5-a]pyridine  Pyrazole  Fluorescence
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