Salvifarinin A,a neo-clerodane diterpenoid with a 6/5/7 tricyclic skeleton from Salvia farinacea |
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| Authors: | Min Fan Xue-Jiao Chen Xing-De Wu Li-Dong Shao Xu Ji Qin-Shi Zhao |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;2. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China |
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| Abstract: | Salvifarinin A (1), a rearrangement product of Languidulane-type clerodane diterpenoids with a 6/5/7 tricyclic ring skeleton fused with γ-lactone ring and furan ring, and two new biogenetically related diterpernoids, salvifarinins B (2) and C (3), were isolated from the aerial parts of Salvia farinacea. The absolute configuration of 1 was elucidated by extensive spectroscopic methods, and confirmed by single crystal X-ray diffraction and bio-inspired semisynthesis. The plausible biogenetic pathway was also proposed. Compound 2 displayed a potent effect on reducing hepatic steatosis. |
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| Keywords: | Lipid-lowering activity |
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