Decarbonylative radical conjugate addition of aliphatic aldehydes for alkylation of electron-deficient alkenes |
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| Authors: | Yu-Xia Li Wei-Yu Li Yuan-Yuan Jiang Luo Yang |
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| Affiliation: | Key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry, Xiangtan University, Hunan 411105, PR China |
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| Abstract: | A convenient metal-free decarbonylative radical conjugate addition of aliphatic aldehydes to electron-deficient alkenes is developed. With DTBP as an oxidant and radical-initiator, this reaction smoothly converts α-unsubstituted, α-mono-substituted and α-di-substituted aliphatic aldehydes into the corresponding primary, secondary and tertiary alkyl radicals, and subsequently allows for the cascade construction of C(sp3) | |
| Keywords: | Radical conjugate addition Decarbonylation Alkylation Aliphatic aldehyde Alkene |
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