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Cu(I)-catalyzed cascade intramolecular cyclization of 2-propynol phenyl azides and diarylphosphine oxides for the synthesis of bisphosphorylated indole derivatives |
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| Authors: | Xian-Rong Song Ren Li Tao Yang Jiang Bai Ruchun Yang Xi Chen Haixin Ding Qiang Xiao Yong-Min Liang |
| Affiliation: | 1. Institute of Organic Chemistry, Jiangxi Science & Technology Normal University, Key Laboratory of Organic Chemistry, Jiangxi Province, Nanchang 330013, China;2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
| Abstract: | The [Cu(OTf)]2·C6H6 catalyzed cascade intermolecular addition–intramolecular cyclization reaction of easily prepared 2-propynol phenyl azides and diarylphosphine oxides was developed. This novel reaction leads to simultaneous formation of one C–N and two C–P bonds in a single step to give bisphosphorylated indole derivatives under mild conditions in moderate to good yields. |
| Keywords: | 2-Propynol phenyl azides Bisphosphorylated indoles Copper-catalyzed Cascade cyclization |
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