Synthesis,structure, and antimicrobial activity of methyl (4-alkanoyl-1,5-diaryl-2-hydroxy-3-oxo-2,3-dihydro-1<Emphasis Type="Italic">H</Emphasis>-pyrrol-2-yl)acetates |
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| Authors: | P P Mukovoz A V Gorbunova P A Slepukhin O S El’tsov I N Ganebnykh A N Sizentsov I V Korobova |
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| Institution: | 1.Orenburg Branch,Moscow Institute of Technology,Orenburg,Russia;2.Orenburg State University,Orenburg,Russia;3.Postovskii Institute of Organic Synthesis, Ural Branch,Russian Academy of Sciences,Yekaterinburg,Russia;4.Yeltsin Ural Federal University,Yekaterinburg,Russia |
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| Abstract: | Reactions of methyl 3,4,6-trioxoalkanoates (3,4-dihydroxy-6-oxo-2,4-alkadienoates) with mixtures of aromatic aldehydes and arylamines or with the corresponding N-(arylmethylidene)anilines afforded methyl (4-alkanoyl-1,5-diaryl-2-hydroxy-3-oxo-2,3-dihydro-1H-pyrrol-2-yl)acetates. The product structure was discussed on the basis of their IR, 1H NMR, and mass spectra and X-ray diffraction data, and their antimicrobial activity against Staphylococcus aureus P-209 and Escherichia coli M17 was evaluated. |
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