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Decarboxylative difluoromethylation of aldehydes with PhSO2CF2COOK: A facile and efficient access to difluoromethylated carbinols |
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| Authors: | Yu-Jun Zhu Zhong-Liang Lei Da-Kang Huang Bo Lian Zhen-Jiang Liu Xiao-Jun Hu Jin-Tao Liu |
| Affiliation: | 1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China;2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China |
| Abstract: | A novel decarboxylative difluoromethylation reaction of PhSO2CF2COOK with aldehydes under metal- and ligand-free conditions has been developed. The reaction is very mild and tolerates a wide range of aldehydes (both enolizable and non-enolizable aldehydes), providing a facile and efficient method for the synthesis of structurally diverse difluoromethylated carbinols in moderate to excellent yields. |
| Keywords: | Decarboxylative difluoromethylation Addition Potassium phenylsulfonyldifluoroacetate Difluoromethyl alcohol |
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