Highly efficient organic photosensitizer with aggregation-induced emission for imaging-guided photodynamic ablation of cancer cells |
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| Authors: | Yipeng Li Qi Yu Pengli Gao Huiran Yang Tianci Huang Shujuan Liu Qiang Zhao |
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| Institution: | Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210023, PR China |
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| Abstract: | We design an organic photosensitizer with a donor-π-acceptor configuration. The photosensitizer exhibits aggregation-induced emission characteristics and efficient singlet oxygen production in the aggregated state. It is then enveloped into the water-soluble micelle to afford a nanoprobe. The water-soluble nanoprobe keeps the photosensitizer in the aggregation state and is used for imaging-guided photodynamic ablation of cancer cells. |
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| Keywords: | Photodynamic therapy Photosensitizer Donor-π-acceptor configuration Aggregation induced emission |
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