One-pot three-component green synthesis of novel dihydrophthalazine-1,4-diones |
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| Authors: | M Suman B Vijayabhaskar U K Syam Kumar B Venkateswara Rao |
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| Institution: | 1.Process Research & Development,Dr. Reddy’s Laboratories Limited, API Plant, IDA,Pydibhimavaram, Ranasthalam Mandal,India;2.GVK Bio sciences PVT LTD,Mallapur, Hyderabad,India;3.Integrated Product Development, Innovation Plaza,Dr. Reddy’s Laboratories Ltd.,Bachupalli, Qutubullapur,India;4.Department of Organic Chemistry, Foods, Drugs, and Water,Andhra University,Visakhapatnam,India |
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| Abstract: | Green and efficient one-pot three-component synthesis of novel 2-(7-amino-2,2-dimethyl-4-oxo-5-phenyl-4,5-dihydropyrano2,3-d]1,3]dioxin-6-ylcarbonyl)-2,3-dihydrophthalazine-1,4-diones have been developed by condensing 3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-2-yl)-3-oxopropanenitrile with benzaldehydes and Meldrum’s acid using L-proline as catalyst in ethanol at room temperature. The products have been isolated as pure compounds in good yields without using column chromatography. |
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