Copper diisobutyl-t-butoxyaluminum hydride: A novel reagent for chemoselective reduction of tertiary amides over esters |
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| Authors: | So Hee Im Won Kyu Shin Ashok Kumar Jaladi Duk Keun An |
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| Institution: | Department of Chemistry, Kangwon National University, and Institute for Molecular Science and Fusion Technology, Chunchon 24341, Republic of Korea |
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| Abstract: | We demonstrate that copper diisobutyl-t-butoxyaluminum hydride, readily prepared from lithium diisobutyl-t-butoxyaluminum hydride and CuI, effectively and chemoselectively reduces tertiary amides over esters at ambient temperature, affording the corresponding aldehydes in excellent yields. |
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| Keywords: | Chemoselective reduction Tertiary amide Ester Aldehyde CDBBA |
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