Tandem synthesis of aromatic amides from styrenes in water |
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| Authors: | Pratima A Sathe Aniket S Karpe Aniket A Parab Babasao S Parade Kamlesh S Vadagaonkar Atul C Chaskar |
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| Institution: | 1. National Centre for Nanosciences and Nanotechnology, University of Mumbai, Mumbai 400098, India;2. Department of Dyestuff Technology, Institute of Chemical Technology, Mumbai 400019, India |
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| Abstract: | An expedient one-pot synthesis of aromatic amides has been reported from styrenes in the presence of N-bromosuccinimide and iodine by using aqueous ammonia in water. The reaction proceeds through the formation of α-bromoketone as an intermediate in the presence of NBS and water. α-Bromoketone on reaction with iodine forms bromodiiodoketone which on nucleophilic substitution with aqueous ammonia gives aromatic amide. Substituted aromatic amides were obtained in good yields with wide functional group compatibility. |
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| Keywords: | Aromatic amides Iodine Styrenes Water |
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