Transition metal free large-scale synthesis of aromatic vinyl chlorides from aromatic vinyl carboxylic acids using bleach |
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| Authors: | Navnath T. Hatvate Balaram S. Takale Shrikant M. Ghodse Vikas N. Telvekar |
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| Affiliation: | 1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400 019, Maharashtra, India;2. Department of Chemistry and Biochemistry, University of California, Santa Barbara 93106, USA |
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| Abstract: | While continuing our research on Hunsdiecker reaction, we came across an interesting application of bleach, sodium hypochlorite (NaOCl) for decarboxylative chlorination reaction. The reaction is easily scaled up to 10?mmol. The reaction has good tolerance towards wide variety of functional groups. The reaction has mild conditions and gave relatively high chemical yield of the desired product. |
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| Keywords: | Acids Chlorides α,β-Unsaturated Decarboxylation Hypochlorite |
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