Novel approach to 6-alkenyl-substituted pyridoxine derivatives based on the Heck reaction |
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| Authors: | Timur M. Bulatov Mikhail V. Pugachev Nikita V. Shtyrlin Yurii G. Shtyrlin |
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| Affiliation: | Kazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, Russia |
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| Abstract: | A new synthetic approach to 6-alkenyl-substituted pyridoxine derivatives was developed based on the Heck reaction. The reaction, which was catalyzed using a mixture of Pd(OAc)2, (o-Tol)3P and Bu3N as a base, led to seven new 6-alkenyl pyridoxine derivatives. When acrylic acid was used the products of decarboxylation and dimerization were formed. |
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| Keywords: | Pyridoxine Heck reaction Decarboxylation |
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