Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids |
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| Authors: | Tatyana Sharonova Vitalina Pankrat&#x;eva Polyna Savko Sergey Baykov Anton Shetnev |
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| Institution: | 1. Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University, 108 Respublikanskaya St., Yaroslavl 150000, Russian Federation;2. Institute of Chemistry, Saint Petersburg State University, Universitetsky pr. 26, Saint Petersburg 198504, Russian Federation |
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| Abstract: | A one-pot ambient-temperature procedure for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and carboxylic acids under superbase-promoted conditions is reported. |
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| Keywords: | Heterocycles Amidoximes Carboxylic acids Superbase promoted Room temperature synthesis |
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