A short and divergent route to 2-alkenyl-4-quinolones |
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| Authors: | Bernhard Lohrer Franz Bracher |
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| Affiliation: | Ludwig-Maximilians University, Department of Pharmacy – Center for Drug Research, Butenandtstr. 5-13, 81377 Munich, Germany |
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| Abstract: | 2-alkenyl-4-quinolones were accessed via a high-yielding, three-step synthesis starting from 2-methyl-4-quinolones using a one-pot phosphorylation-olefination sequence as the key step and SEM as a convenient protecting group. This protocol tolerates various functional groups and gives the target olefins with complete (E)-selectivity. |
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| Keywords: | 4-Quinolones Alkaloid Olefination Horner-Wadsworth-Emmons reaction |
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