Pd-catalyzed C-N coupling of primary (het)arylamines with 5-substituted 3-chloro-4H-1,2,6-thiadiazin-4-ones |
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| Authors: | Andreas S Kalogirou Panayiotis A Koutentis |
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| Institution: | 1. Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P. O. Box 22006, 1516 Nicosia, Cyprus;2. Department of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, Cyprus |
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| Abstract: | The Buchwald-Hartwig Pd-catalyzed C-N coupling reaction of 5-substituted 3-chloro-4H-1,2,6-thiadiazin-4-ones with primary (het)arylamines is described, affording twenty new 3,5-disubstituted 4H-1,2,6-thiadiazin-4-ones in 56–99% yield. The protocol enables the mild preparation of difficult to access 3,5-dianilino-1,2,6-4H-thiadiazin-4-ones. The reaction scope and limitations are discussed. |
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| Keywords: | Buchwald coupling Heterocycle 1 2 6-thiadiazines C-N coupling Superstable Pd(0) |
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