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Stereodivergent synthesis of novel chiral C2-symmetric bis-trifluoromethyl-2-oxazolidinones |
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| Authors: | Travis Remarchuk EJ Corey |
| Institution: | Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, United States |
| Abstract: | A simplified effective synthetic process is described for the diastereoselective synthesis of the chiral C2-symmetric CF3-ureas (R,R)-15 and (S,S)-15 from (S)-α-phenylethylamine, glyoxal and CF3I. |
| Keywords: | Nucleophilic trifluoromethylation Stereoselective Chiral 2-oxazolidinone Vicinal diamine [2+1]-Cycloaddition |
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