Total synthesis of modified pentapeptide,caldoramide |
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| Authors: | Kishore Kumar Anantoju Thirumala Chary Maringanti Baquer Syed Mohd. |
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| Affiliation: | 1. Discovery Chemistry, GVK Biosciences Pvt. Ltd., Survey Nos: 125 (part) & 126, IDA, Mallapur, Hyderabad 500076, India;2. Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500 085, India |
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| Abstract: | Total synthesis of modified pentapeptide, caldoramide, a cytotoxic linear pentapeptide from the marine cyanobacterium Caldora penicillate is described. Notable features of the route include the efficient preparation of three key fragments and final assembly to the natural product via sequential amide couplings. The spectral data of the synthetic compound was found to be in comparison with that of the isolated natural product. |
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| Keywords: | Natural product Anti-cancer Peptides Cytotoxic Total synthesis |
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