Site-selective C–H nitration of N-aryl-7-azaindoles under palladium(II) catalysis |
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Authors: | Rina Chun Saegun Kim Sang Hoon Han Ashok Kumar Pandey Neeraj Kumar Mishra In Su Kim |
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Institution: | School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea |
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Abstract: | The site-selective C–H nitration reaction of 7-azaindoles with t-butyl nitrite under palladium catalysis is described. This protocol provides an efficient method for the construction of ortho-nitrated N-aryl-7-azaindoles with excellent site-selectivity and functional group compatibility. The formed 7-azaindole derivatives can be readily transformed into 7-azaindoles containing an aniline functional group under palladium-catalyzed hydrogenation conditions. |
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Keywords: | Azaindoles C–H functionalization Palladium Nitration Regioselectivity |
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