Copper(I)-catalyzed synthesis of 3,3-disubstituted isoindolin-1-ones from enamides via cascade radical addition and cyclization |
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| Authors: | Hui Yu Pengfei Xuan Jingbo Lin Mingdong Jiao |
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| Affiliation: | School of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Substainability, Tongji University, 1239 Siping Road, Shanghai 200092, PR China |
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| Abstract: | Copper(I) catalyzed radical benzylation and cyclization reaction of tertiary enamides was investigated and 3,3-disubstituted N-Alkyl isoindolin-1-ones were obtained in moderate to good yields. In this reaction, two new C–C bonds were formed in one step with high atom economy. Possible reaction pathway for the formation of the products was also discussed in this paper. |
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| Keywords: | Copper(I)-catalyzed Radical Enamides DTBP Benzylation |
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