Synthesis of enantiomerically-enriched N-aryl amino-amides via a Jocic-type reaction |
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| Authors: | Christian Hobson Michael S. Perryman Gavin Kirby Guy J. Clarkson David J. Fox |
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| Affiliation: | Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK |
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| Abstract: | Enantiomerically-enriched secondary trichloromethyl-alcohols react with aryl amines to give enantiomerically-enriched α-N-arylamino-acid derivatives. The intermediate acid chlorides can react in situ with aryl or, regioselectively, with alkyl amines to give aryl or alkyl α-N-arylamino amides. |
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| Keywords: | Jocic reaction Enantiomerically-enriched |
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