Synthesis and antimicrobial screening of novel 9-{2-[(1<Emphasis Type="Italic">H</Emphasis>-1,2,3-triazol-4-yl)methoxy]phenyl}-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1<Emphasis Type="Italic">H</Emphasis>-xanthene-1,8(2<Emphasis Type="Italic">H</Emphasis>)-dione derivatives |
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Authors: | A Kishore Kumar V Sunitha B Shankar T Murali Krishna Ch Abraham Lincoln P Jalapathi |
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Institution: | 1.Department of Chemistry,University College of Science, Osmania University,Saifabad, Hyderabad,India;2.Department of Biotechnology,Chaitanya Postgraduate College (Autonomous),Kishanpura, Hanamkonda, Warangal,India |
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Abstract: | A series of novel 9-{2-(1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized by a click chemistry approach. The structures of all the newly synthesized compounds were characterized by IR, MASS, 1H and 13C NMR spectral data. The final analogues showed good to excellent antibacterial and antifungal activities in an agar well diffusion assay. Compounds 6i and 6f were the most active against all the test bacterial and fungal strains. |
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