Se-mediated one-pot synthesis of 2-substituted benzoselenazole derivatives from 2 to iodoanilines and arylacetic acids/arylmethyl chlorides |
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| Authors: | Ren Gu Xin Wang Zhao Yang Shiqing Han |
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| Affiliation: | 1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China;2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Road, Shanghai 200032, China |
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| Abstract: | A general approach to the formation of 2-substituted benzoselenazoles from the three-component reactions of 2-iodoanilines, selenium powder, arylacetic acids or benzyl chlorides is described. The use of copper salt as catalyst and dimethyl sulfoxide (DMSO) as solvent are crucial to afford the title compounds in moderate to good yields (45–88%) with good functional group tolerance on the aromatic and heteroaromatic substrates. |
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| Keywords: | Benzoselenazoles 2-Iodoanilines Selenium powder Synthetic methods |
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