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Synthesis of double-13C-labeled imidazole derivatives |
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| Authors: | Hitoshi Ouchi Tomohiro Asakawa Kazutada Ikeuchi Makoto Inai Jae-Hoon Choi Hirokazu Kawagishi Toshiyuki Kan |
| Institution: | 1. School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan;2. Tokai University Institute of Innovative Science and Technology, 4-1-1, Kitakaname, Hiratsuka-city, Kanagawa 259-1292, Japan;3. Department of Chemistry, Faculty of Science, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo 060-0810, Japan;4. Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan;5. Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan |
| Abstract: | Double-13C-labeled imidazole-4-carboxamide (ICA: 13C2-1) and 5-aminoimidazole-4-carboxamide-1-β-riboside (AICAr: 13C2-5) were synthesized from stable isotope-labeled sodium cyanide and triethyl orthoformate. The key intermediate, 4-aminoimidazole-5-carboxamide (AICA: 13C2-4), should also provide access to double-13C-labeled histidine and adenosine derivatives via reported methods. |
| Keywords: | Isotope label Fairy chemicals (FCs) Double-label Histidine Adenosine riboside |
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