Two new tricycloalternarenes from Hawaiian endophytic fungus Didymella sp. FT433 |
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| Authors: | Chunshun Li Zhenquan Hu Qingsong Liu Xiaohua Wu Shugeng Cao |
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| Institution: | 1. Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 200 West Kawili Street, Hilo, Hawai''i 96720, United States;2. Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, Hawai''i 96813, United States;3. High Magnetic Field Laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, PR China |
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| Abstract: | Two new compounds, tricycloalterenes M and N (1 and 2) and six known analogs were isolated from the cultured broth of Didymella sp. FT433. The structures of all the compounds were elucidated through the analysis of HRMS and NMR spectroscopic data. The absolute configurations (AC) of the new compounds were determined by CD. All compounds were tested against A2780 and cisplatin resistant A2780 (A2780CisR) cell lines, and pathogenic bacteria Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa, but none was active. |
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| Keywords: | Endophytic fungi Tricycloalterene Hawai'i Bioactivity |
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