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Stellatolide H,a cytotoxic peptide lactone from a deep-sea sponge Discodermia sp. |
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| Authors: | Shohei Nakamukai Kentaro Takada Kazuo Furihata Yuji Ise Shigeru Okada Yasuhiro Morii Nobuhiro Yamawaki Tomohiro Takatani Osamu Arakawa Kirk R Gustafson Shigeki Matsunaga |
| Institution: | 1. Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8675, Japan;2. Advanced Instrumental Analysis Unit, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8675, Japan;3. Sugashima Marine Biological Laboratory, Nagoya University, Mie 517-0004, Japan;4. Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki 852-8521, Japan;5. Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States |
| Abstract: | Stellatolide H (1) was isolated from a deep-sea sponge Discodermia sp. as the cytotoxic constituent. The planar structure of 1 was elucidated on the basis of the NMR spectroscopic and mass spectrometric data. The absolute configurations of the constituent amino acid residues were determined by the Marfey’s method. Stellatolide H (1) is a peptide lactone of the callipeltin class with its N-terminus blocked by 3-hydroxy-6,8-dimethyldeca-(4Z,6E)-dienoic acid (Hdda). |
| Keywords: | Marine natural products Marine sponge Peptide lactone Structure elucidation Cytotoxic |
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