Al(OTf)3-catalyzed one-pot synthesis of pyrrolo[3,2-d]pyrimidinedione derivatives |
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| Authors: | Sudipta Ponra Mukut Gohain Rajashekar Donka Johannes H. van Tonder Barend C.B. Bezuidenhoudt |
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| Affiliation: | Department of Chemistry, University of the Free State, PO Box 339, Bloemfontein 9300, South Africa |
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| Abstract: | A series of polysubstituted pyrrolo[3,2-d]pyrimidinedione derivatives have been synthesized in excellent yields. This prominent scaffold is obtained via an Al(OTf)3-catalyzed tandem addition-annulation sequence between propargylic alcohols and aminopyrimidines. The process is simple, facile, inexpensive, and provides a diverse range of substituted pyrrolo [3,2-d]pyrimidinedione derivatives with short reaction times from readily obtainable starting materials. |
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| Keywords: | Lewis acid catalysis Aminopyrimidine Propargylic alcohol |
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