Selective ruthenium-catalyzed double reductive aminations using hydrosilane to access tertiary amines and piperidine derivatives |
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| Authors: | Bin Li Shun Liu Minhua Wu Qiao Lin Wanhong Deng Shaohua Jiang Lu Chen |
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| Affiliation: | School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, PR China |
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| Abstract: | A highly selective double reductive aminations of aldehydes with anilines to give tertiary amines, in the presence of [RuCl2(p-cymene)]2 catalyst and PhSiH3, was performed under neat conditions. Piperidine derivatives were successfully synthesized by a double reductive amination followed by cyclisation from glutaric dialdehyde with anilines. |
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| Keywords: | Reductive Amination Ruthenium Catalysis Hydrosilylane Tertiary Amines Piperidines |
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