Protected pyrimidine nucleosides for cell-specific metabolic labeling of RNA |
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Authors: | Samantha Beasley Kim Nguyen Michael Fazio Robert C Spitale |
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Institution: | 1. Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, United States;2. Department of Chemistry, University of California, Irvine, Irvine, CA 92697, United States |
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Abstract: | RNA molecules can perform a myriad of functions, from the regulation of gene expression to providing the genetic blueprint for protein synthesis. Characterizing RNA expression dynamics, in a cell-specific manner, still remains a great challenge in biology. Herein we present a new set of protected alkynyl nucleosides for cell-specific metabolic labeling of RNA. We anticipate these analogs will find wide spread utility toward the goal of understanding RNA expression in complex cellular and tissue environments, even within living animals. |
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Keywords: | RNA Metabolic labeling Alkynyl nucleosides |
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