Selective synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines via copper-catalyzed tandem annulation of alkynylbenzonitriles with 2-Iodoanilines |
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| Authors: | Xiaodong Liu Guobo Deng Yun Liang |
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| Institution: | National & Local Joint Engineering Laboratory for New Petro-Chemical Materials and Fine Utilization of Resources, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Key Laboratory of the Assembly and Application of Organic Functional Molecules, Hunan Normal University, Changsha, Hunan 410081, China |
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| Abstract: | An efficient copper-catalyzed cascade cyclization reaction for selectively synthesizing a variety of benzo4,5]imidazo2,1-a]isoquinoline derivatives has been developed. The reaction features the formation of three different C![/>N bonds in sequence. In the presence of Cu(OAc)<sub>2</sub> and KO<em><sup>t</sup></em>Bu, <em>o</em>-alkynylbenzonitriles and 2-iodoanilines proceeded smoothly to obtain the corresponding benzo4,5]imidazo2,1-<em>a</em>]isoquinolines in moderate to good yields.</td>
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| Keywords: | 2-Iodoaniline Nitrogen heterocycles Cycloaddition Tandem reaction |
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