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A simple approach for the synthesis of azocine alkaloids: The total synthesis of megallanesine |
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| Authors: | Prajesh S Volvoikar Santosh G Tilve |
| Institution: | 1. Department of Chemistry, Goa University, Taleigao Plateau, Goa 403206, India;2. Organic Chemistry Department, RUDN University, 6 Miklukcho-Maklaya Str., Moscow 117198, Russian Federation |
| Abstract: | A new three step synthetic route to construct azocine ring system using anion chemistry and intramolecular Friedel-Craft reaction of an ester is presented. This method allows synthesis of azocine ring analogues in excellent overall yields. The designed strategy was applied for the synthesis of naturally occurring magallanesine. |
| Keywords: | Alkaloids Isoindolinone Intramolecular Friedel-Craft Azocine Magallanesine |
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