Novel approach towards 3,7-disubstituted 1,6-naphthyridin-4(1H)-ones exploiting cross-coupling and SNAr reactions of a dihalogenated compound |
| |
| Authors: | Ousmane Dembélé David Montoir Thomas Yvorra Dylan Sérillon Alain Tonnerre Muriel Duflos Jean-Michel Robert Marc-Antoine Bazin |
| |
| Institution: | Département de Chimie Thérapeutique, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Institut de Recherche en Santé 2, 22 Boulevard Bénoni Goullin, F-44200 Nantes, France |
| |
| Abstract: | A new route towards the synthesis of a series of 3,7-disubstituted 1,6-naphthyridin-4(1H)-ones in moderate to good yields is reported. The strategy involves the preparation of a 3,7-dihalogenated compound that undergoes differential functionalization using palladium-catalyzed cross-coupling and SNAr reactions. |
| |
| Keywords: | Suzuki-Miyaura reaction Buchwald-Hartwig amination Nucleophilic aromatic substitution Halodecarboxylation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
