Synthesis of substituted phenols via 1,1-dichloro-2-nitroethene promoted condensation of carbonyl compounds with DMF |
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Authors: | Fukai Wang Wei Wu Xiaoyong Xu Xusheng Shao Zhong Li |
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Affiliation: | 1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;2. Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, China |
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Abstract: | A novel and efficient metal-free synthesis of phenolic compounds was developed via coupling cyclization of DMF as a carbon source with active methylene compounds such as 1,3-dicarbonyl compounds with the assistance of 1,1-dichloro-2-nitroethene. The method we used was different from other traditional phenol functionalization methods. In the reaction, the 1,1-dichloro-2-nitroethene as a promoter which unlike our previous research on 1,1-dichloro-2-nitroethene. The method allows the convenient construction of phenolic compounds under mild reaction conditions and moderate yields. |
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Keywords: | 1,1-Dichloro-2-nitroethene β-Dicarbonyl Phenolic Cyclization |
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