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Synthesis of 6-acylpyrido[2,3-<Emphasis Type="Italic">d</Emphasis>]pyrimidine derivatives from 5-acetyl-4-aminopyrimidine hydrochlorides |
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| Authors: | A V Komkov V A Dorokhov |
| Institution: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation |
| Abstract: | Reaction of 2,6-disubstituted 5-acetyl-4-aminopyrimidine hydrochlorides with acetylacetone or benzoylacetone afforded new substituted 6-acylpyrido2,3-d]pyrimidines. The reaction of these hydrochlorides with ethyl acetoacetate also proceeds according to the classical version of the Friedländer condensation to form the corresponding pyrido2,3-d]pyrimidine-6-carboxylic acid esters. |
| Keywords: | 2 6-disubstituted 5-acetyl-4-aminopyrimidine hydrochlorides acetylacetone benzoylacetone ethyl acetoacetate the Friedl?nder reaction 6-acylpyrido[2 3-d]pyrimidines ethyl pyrido[2 3-d]pyrimidine-6-carboxylates |
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