Determination of acidity constants of curcumin in aqueous solution and apparent rate constant of its decomposition |
| |
Authors: | Bernabé-Pineda Margarita Ramírez-Silva María Teresa Romero-Romo Mario González-Vergara Enrique Rojas-Hernández Alberto |
| |
Institution: | Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Area de Química Analítica, Apdo. Postal 55-534, C.P. 09340, México, D.F. México. |
| |
Abstract: | The stability of curcumin (H3Cur) in aqueous media is improved when the systems in which it is present are at high pH values (higher than 11.7), fitting a model describable by a pseudo-zero order with a rate constant k' for the disappearance of the Cur3- species of 1.39 (10(-9)) Mmin(-1). There were three acidity constants measured for the curcumin as follows: pKA3 = 10.51 +/- 0.01 corresponding to the equilibrium HCur2- = Cur3- + H+, a pKA2 = 9.88 +/- 0.02 corresponding to the equilibrium H2Cur- = HCur-(2) + H+. These pKA values were attributed to the hydrogen of the phenol part of the curcumin, while the pKA1 = 8.38 +/- 0.04 corresponds to the equilibrium H3Cur = H2Cur- + H+ and is attributed the acetylacetone type group. Formation of quinoid structures play an important role in the tautomeric forms of the curcumin in aqueous media, which makes the experimental values differ from the theoretically calculated ones, depending on the conditions adopted in the study. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|