| THE ROLE OF INSULIN MEDIATORS IN REGULATION OF cAMP AND LIPOGENESIS AS WELL AS IN DIABETES |
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| 作者姓名： | 张世荣 魏铁拳 姚文贞 韩锦华 幸兴球 王越 王敬泽 乐云 |
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| 作者单位： | Department of Endocrinology，Institute of Zoology，Academia Sinica，Beijing，Department of Endocrinology，Institute of Zoology，Academia Sinica，Beijing，Department of Endocrinology，Institute of Zoology，Academia Sinica，Beijing，Department of Endocrinology，Institute of Zoology，Academia Sinica，Beijing，Department of Endocrinology，Institute of Zoology，Academia Sinica，Beijing，Department of Endocrinology，Institute of Zoology，Academia Sinica，Beijing，Department of Endocrinology，Institute of Zoology，Academia Sinica，Beijing，Department of Endocrinology，Institute of Zoology，Academia Sinica，Beijing |
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| 基金项目： | This work was supported by a grant from the Chinese Academy of Sciences. |
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| 摘 要： | Plasma membranes prepared from pig, mouse and rat liver incubated with insulin resulted in the release of at least two insulin chemical mediators. These mediators, identified as fractions 1 and 3, were found to inhibit cAMP level in response to lipolytic hormone and forskolin and to enhance lipogenesis in adipocytes of rat. Fractions 1 and 3 have been estimated to have molecular weights of 3700—4000 and 1000—1500 dalton, respectively. This initial report will focus on fraction 1.Interestingly, liver membranes from diabetic animals were found not to release mediators in the presence of insulin. However, following in vivo treatment of diabetic animals with insulin, the liver membranes appeared to restore its ability in generating chemical mediators in response to insulin.
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