Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold |
| |
| Authors: | Marian Christine Huang Rong Borch Richard F |
| |
| Affiliation: | Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA |
| |
| Abstract: | Synthesis of a potential Src family SH2 domain inhibitor incorporating a 1,4-cis-enediol scaffold is reported. The synthetic route offers straightforward and highly selective access to the enediol and its associated chiral centers. Key steps include stereocontrolled syn-aldol coupling, amide alkynylation, and asymmetric ketone reduction. |
| |
| Keywords: | cis-Enediol SH2 domain Stereodiversified Alkynylation |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
