Direct evidence for degradation of esperamicin A1 with thiol confirmed by fast-atom bombardment mass spectrometry. |
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| Authors: | M Takayama T Nomura M Konishi |
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| Institution: | Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Japan. |
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| Abstract: | A degradation of esperamicin A1, which is a potent antitumor antibiotic having DNA-cleaving activity, was studied by fast-atom bombardment (FAB) mass spectrometry. It was proved that the degradation easily occurs via the thiol group(s) in the matrix solution and not by a FAB-induced reaction. It was concluded that from the FAB mass spectra of all non-volatile compounds, the molecular weight should be determined by using at least two chemically different matrices. |
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