Application of nonionic amphiphiles for increasing solubility in water of alkylated bibenzimidazole derivatives |
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| Authors: | A B Mirgorodskaya F G Valeeva N A Zhukova V A Mamedov L Ya Zakharova O G Sinyashin |
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| Institution: | 1.A. E. Arbuzov Institute of Organic and Physical Chemistry,Kazan Scientific Center of the Russian Academy of Sciences,Kazan,Russian Federation;2.Kazan National Research Technological University,Kazan,Russian Federation |
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| Abstract: | Solubilization capacity of a number of nonionic micelle-forming compounds toward 2,2´-bibenzimidazole and its alkylated derivatives was determined by spectrophotometry. It was found that as the hydrophilic lipophilic balance of the studied amphiphiles grows, their solubilization effect toward 2,2´-bibenzimidazoles increases and reaches the highest value in the case of pluronic F127. The conversion of bibenzimidazoles to the cationic form induced by lowering the medium pH improves efficiency of the solubilizers. |
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