Epilepsy is related to theta band brain connectivity and network topology in brain tumor patients |
| |
Authors: | Linda Douw Edwin van Dellen Marjolein de Groot Jan J Heimans Martin Klein Cornelis J Stam and Jaap C Reijneveld |
| |
Institution: | (1) Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands;(2) Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands;(3) Department of Clinical Neurophysiology, VU University Medical Center, Amsterdam, The Netherlands |
| |
Abstract: | Background Both epilepsy patients and brain tumor patients show altered functional connectivity and less optimal brain network topology
when compared to healthy controls, particularly in the theta band. Furthermore, the duration and characteristics of epilepsy
may also influence functional interactions in brain networks. However, the specific features of connectivity and networks
in tumor-related epilepsy have not been investigated yet. We hypothesize that epilepsy characteristics are related to (theta
band) connectivity and network architecture in operated glioma patients suffering from epileptic seizures. Included patients
participated in a clinical study investigating the effect of levetiracetam monotherapy on seizure frequency in glioma patients,
and were assessed at two time points: directly after neurosurgery (t1), and six months later (t2). At these time points, magnetoencephalography
(MEG) was recorded and information regarding clinical status and epilepsy history was collected. Functional connectivity was
calculated in six frequency bands, as were a number of network measures such as normalized clustering coefficient and path
length. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|