Nanoparticles based on novel amphiphilic polyaspartamide copolymers |
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Authors: | Emanuela Fabiola Craparo Girolamo Teresi Maria Chiara Ognibene Maria Pia Casaletto Maria Luisa Bondì and Gennara Cavallaro |
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Institution: | 1.Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo, via Archirafi 32, 90123, Palermo, Italy ;2.Istituto per lo Studio dei Materiali Nanostrutturati, Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146, Palermo, Italy ; |
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Abstract: | In this article, the synthesis of two amphiphilic polyaspartamide copolymers, useful to obtain polymeric nanoparticles without
using surfactants or stabilizing agents, is described. These copolymers were obtained starting from α,β-poly-(N-2-hydroxyethyl)-dl-aspartamide (PHEA) by following a novel synthetic strategy. In particular, PHEA and its pegylated derivative (PHEA-PEG2000) were functionalized with poly(lactic acid) (PLA) through 1,1′-carbonyldiimidazole (CDI) activation to obtain PHEA–PLA and
PHEA-PEG2000–PLA graft copolymers, respectively. These copolymers were properly purified and characterized by 1H-NMR, FT-IR, and Size Exclusion Chromatography (SEC) analyses, which confirmed that derivatization reactions occurred. Nanoparticles
were obtained from PHEA–PLA and PHEA-PEG2000–PLA graft copolymers by using the high pressure homogenization-solvent evaporation method, avoiding the use of surfactants
or stabilizing agents. Polymeric nanoparticles were characterized by dimensional analysis, before and after freeze-drying
process, and Scanning Electron Microscopy (SEM). Zeta potential measurements and X-ray Photoelectron Spectroscopy (XPS) analysis
demonstrated the presence of PEG and/or PHEA onto the PHEA-PEG2000–PLA and PHEA–PLA nanoparticle surface, respectively. |
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