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Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats |
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| Authors: | Kenneth V Christensen Henrik Leffers William P Watson Connie Sánchez Pekka Kallunki and Jan Egebjerg |
| Institution: | (1) Dept. of Molecular Biology, Discovery Biology Research, H. Lundbeck A/S, Valby, DK-2500, Denmark;(2) University Dept. of Growth and Reproduction, Rigshospitalet, Copenhagen, DK-2100, Denmark;(3) Dept. of Neuropharmacology, H. Lundbeck A/S, Valby, DK-2500, Denmark;(4) Teva Pharmaceutical Ltd, The Gate House, Gatehouse Way, Aylesbury, UK;(5) Dept. of Neuroscience, Lundbeck Research Inc. USA, Paramus, NJ, USA |
| Abstract: | BackgroundThe amygdala-kindled rat is a model for human temporal lobe epilepsy and activity-dependent synaptic plasticity. Hippocampal RNA isolated from amygdala-kindled rats at different kindling stages was analyzed to identify kindling-induced genes. Furthermore, effects of the anti-epileptic drug levetiracetam on kindling-induced gene expression were examined. |
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