Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis |
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Authors: | Motozaki Toru Sawamura Kiyoto Suzuki Akari Yoshida Keigo Ueki Tatsuo Ohara Aiko Munakata Ryosuke Takao Ken-Ichi Tadano Kin-Ichi |
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Affiliation: | Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. |
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Abstract: | [reaction: see text]. We have completed the total synthesis of natural (+)-tubelactomicin A (1), a 16-membered macrolide antibiotic. This Letter presents a highly efficient synthesis of the upper-half segment (C14-C24) and the completion of the total synthesis featuring a high-yielding Stille coupling for the connection of the upper-half and lower-half segments and Mukaiyama macrolactonization for the construction of the entire structure of 1. |
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