| 中孔分子筛SBA-15作为液相色谱固定相以及在巯基化合物分离中的应用 |
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| 引用本文： | 高峰,赵建伟,张松,周峰,金婉,张祥民,杨芃原,赵东元. 中孔分子筛SBA-15作为液相色谱固定相以及在巯基化合物分离中的应用[J]. 高等学校化学学报, 2002, 23(8): 1494-1497 |
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| 作者姓名： | 高峰 赵建伟 张松 周峰 金婉 张祥民 杨芃原 赵东元 |
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| 作者单位： | 复旦大学化学系,上海,200433 |
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| 基金项目： | 国家重点基础研究专项经费 (批准号 :2 0 0 1CB5 10 2 0 2 )，复旦大学 Bio-X/Med-X基金资助 |
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| 摘 要： | 采用共表面活性剂法合成了孔道结构高度有序、孔径较大且粒径均匀的SBA－15颗粒，并在此基础上研究了其作为毛细管液相色谱柱的填料基体的特性。在SBA－15材料上进行C18官能团化前后，分别对4种巯基化合物即半胱氨酸、谷胱甘肽、多巴胺和6－巯基嘌呤进行了分离分析。
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| 关 键 词： | 中孔分子筛 SBA－15 高效液相色谱 固定相 巯基化合物 分离 分析 |
| 文章编号： | 0251-0790(2002)08-1494-04 |
Application of C 18-Modified Mseoporous SBA-15 as the Substrate for High Performance Liquid Chromatography |
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| GAO Feng,ZHAO Jian Wei,ZHANG Song,ZHOU Feng,JIN Wan,ZHANG Xiang Min,YANG Peng Yuan ,ZHAO Dong Yuan. Application of C 18-Modified Mseoporous SBA-15 as the Substrate for High Performance Liquid Chromatography[J]. Chemical Research In Chinese Universities, 2002, 23(8): 1494-1497 |
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| Authors: | GAO Feng ZHAO Jian Wei ZHANG Song ZHOU Feng JIN Wan ZHANG Xiang Min YANG Peng Yuan ZHAO Dong Yuan |
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| Affiliation: | GAO Feng,ZHAO Jian Wei,ZHANG Song,ZHOU Feng,JIN Wan,ZHANG Xiang Min,YANG Peng Yuan *,ZHAO Dong Yuan |
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| Abstract: | C 18 functionalized mesoporous silica SBA 15 with a high surface area was applied in high performance liquid chromatography(HPLC) to separate small biomolecules: cysteine, glutathione, dopamine and 6 thiopurine. Compared to commercial available C 18 column, C 18 SBA 15 has a much higher surface area, which enhances the capillary HPLC resolution by increasing molecular capacity factors. The uniform distributed mesopores in SBA 15 result in HPLC peaks narrower than that of commercial column. Mesoporous SBA 15 can be used as an excellent HPLC stationary phase for special applications for its low cost, easy synthesis and various group modifications. |
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| Keywords: | Mesoporous silica SBA 15 HPLC Mercapto compound |
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