Microbial transformation of the steroidal alkaloid dictyophlebine by Rhizopus stolonifer |
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| Authors: | Devkota Krishna Prasad Choudhary Muhammad Iqbal Nawaz Sarfaraz Ahmed Lannang Alain Meli Lenta Bruno Ndjakou Fokou Patrice Aime Sewald Norbert |
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| Institution: | Institute of Forestry, Tribhuvan University, Kaski, Nepal. devkotakpd@yahoo.com |
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| Abstract: | The microbial transformation of a steroidal alkaloid, dictyophlebine (1) with Rhizopus stolonifer (ATCC 10404) afforded three oxidized metabolites 2-4. Compound 2 was found to be a new product. These metabolites were structurally characterized on the basis of modern spectroscopic techniques. Their inhibitory activity towards acetyl- and butyrylcholinesterase has been evaluated and the new product 2 has been found to be more potent than the parent compound and other metabolites. |
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