Synthesis,Crystal Structure,Cytotoxic and Apoptotic Activity of 2,4-Dichloro-6-methylquinoline on Human Oral Carcinoma Cell Line |
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| Authors: | R K Somvanshi R Subashini V Dhanasekaran G Arulprakash S N Das S Dey |
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| Institution: | (1) Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India;(2) Chemistry Division, School of Science and Humanities, Vellore Institute of Technology, Vellore, 632 014, India;(3) Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, 110029, India |
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| Abstract: | Abstract The present report describes the synthesis, IR spectra, 3-dimensional structure of the compound 2,4-dichloro-6-methylquinoline
and evaluation of its anti-cancer activity using propidium iodide (PI) staining and annexin binding assay techniques. This
derivative of quinoline was synthesized from the mixture of p-toluidine and malonic acid and synthesis has been achieved in a one-pot reaction from an aryl amine, malonic acid and phosphorous
oxychloride. Crystallographic data reveals that the crystals belong to triclinic crystal system with space group P-1 with the unit cell dimensions of a = 7.14(1) ?, b = 11.53(1) ?, c = 11.97(1) ? and α = 90.18° (10), β = 106.31° (10), γ = 91.07° (10). The in vitro anti-cancer assay indicated that compound
has cytotoxic and apoptotic activity on human oral squamous carcinoma (KB) cell line, thus it could be developed as a potent
anti-cancer agent.
Graphical Abstract Synthesis, Crystal Structure, Cytotoxic and Apoptotic Activity of 2,4-Dichloro-6-methylquinoline on Human Oral Carcinoma Cell
Line
R. K. Somvanshia, R. Subashinib, V. Dhanasekaranb, G. Arulprakashb, S. N. Dasc, S. Deya
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| Keywords: | Aryl amine Malonic acid 2 4-Dichloro-6-methylquinoline Crystal structure Flow cytometry Apoptosis |
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