Probing the mechanism of Prins cyclisations and application to the synthesis of 4-hydroxytetrahydropyrans |
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| Authors: | Barry Conor S Bushby Nick Harding John R Hughes Rachael A Parker Gregory D Roe Richard Willis Christine L |
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| Affiliation: | School of Chemistry, University of Bristol, Cantock's Close, Bristol, UKBS8 1TS. chris.willis@bristol.ac.uk. |
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| Abstract: | Trapping intermediates on the Prins cyclisation pathway with carbon-based nucleophiles has given further insight into factors affecting the acid-mediated reactions of homoallylic alcohols with aldehydes, enabling the design of efficient syntheses of 4-hydroxy-2,6-disubstituted tetrahydropyrans. |
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