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Total Synthesis of the Tubulin Inhibitor WF‐1360F Based on Macrocycle Formation through Ring‐Closing Alkyne Metathesis |
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| Authors: | M. Sc. Christian M. Neuhaus M. Sc. Marc Liniger Dr. Martin Stieger Prof. Dr. Karl‐Heinz Altmann |
| Affiliation: | 1. Swiss Federal Institute of Technology (ETH) Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, HCI H405, Wolfgang‐Pauli‐Strasse 10, 8093 Zürich (Switzerland) http://www.pharma.ethz.ch/institute_groups/institute_groups/pharmaceutical_biology/;2. Basilea Pharmaceutica International Ltd. Basel (Switzerland) |
| Abstract: | |
| Keywords: | drug discovery metathesis natural products rhizoxin total synthesis |